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People with heart failure, also known as congestive heart failure (CHF), are educated to undertake various non-pharmacological measures to improve symptoms and prognosis. Such measures include: [2] Moderate physical activity, when symptoms are mild or moderate; or bed rest when symptoms are severe. In individuals with heart failure, increasing ...
Slow heart rate, low blood pressure, nausea, vomiting, sleepiness [1] [2] Complications: Cardiac arrest [2] Usual onset: Within 6 hours [2] Causes: Too much calcium channel blockers either by accident or on purpose [3] Differential diagnosis: Beta blocker toxicity [1] Treatment
Amlodipine's safety in pregnancy has not been established, although reproductive toxicity at high doses is known. Whether amlodipine enters the milk of breastfeeding mothers is also unknown. [7] [6] Those who have heart failure, or recently had a heart attack, should take amlodipine with caution. [29]
Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke, heart failure, kidney failure and myocardial infarction. Evidence suggests that a reduction of blood pressure by 5 mmHg can decrease the risk of stroke by 34% and of ischaemic heart disease by 21%.
Amlodipine/olmesartan, sold under the brand name Azor, among others is a fixed-dose combination medication used to treat high blood pressure. [5] It contains amlodipine , as the besilate, a dihydropyridine calcium channel blocker , and olmesartan medoxomil , an angiotensin II receptor blocker .
Slowing down the conduction of electrical activity within the heart, by blocking the calcium channel during the plateau phase of the action potential of the heart (see: cardiac action potential), results in a negative chronotropic effect, or a lowering of heart rate. This can increase the potential for heart block.
Class IV agents are slow non-dihydropyridine calcium channel blockers. They decrease conduction through the AV node, and shorten phase two (the plateau) of the cardiac action potential. They thus reduce the contractility of the heart, so may be inappropriate in heart failure.
Heart failure (HF), also known as congestive heart failure (CHF), is a syndrome caused by an impairment in the heart's ability to fill with and pump blood. Although symptoms vary based on which side of the heart is affected, HF typically presents with shortness of breath, excessive fatigue, and bilateral leg swelling. [3]