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Retinal regeneration in zebrafish is mediated by Muller glia, which dedifferentiate into stem-like cells and proliferate into neural progenitor cells in response to retinal damage. While Muller glia division is responsible for the regeneration of the retina in all cases of retinal damage, the case of photoreceptor loss due to light damage is ...
The Müller glia cell is the only retinal glial cell that shares a common cell lineage with retinal neurons. A subset of Müller glia has been shown to originate from neural crest cells. [ 3 ] They are shown to be critical to the development of the retina in mice, serving as promoters of retinal growth and histogenesis , via a nonspecific ...
Overview of the retina photoreceptors. ipRGCs labelled at the top-right. Intrinsically photosensitive retinal ganglion cells (ipRGCs), also called photosensitive retinal ganglion cells (pRGC), or melanopsin-containing retinal ganglion cells (mRGCs), are a type of neuron in the retina of the mammalian eye.
Visual phototransduction is the sensory transduction process of the visual system by which light is detected by photoreceptor cells (rods and cones) in the vertebrate retina.A photon is absorbed by a retinal chromophore (each bound to an opsin), which initiates a signal cascade through several intermediate cells, then through the retinal ganglion cells (RGCs) comprising the optic nerve.
A second product of Meta II decay is an all-trans-retinal opsin complex in which the all-trans-retinal has been translocated to second binding sites. Whether the Meta II decay runs into Meta III or the all-trans-retinal opsin complex seems to depend on the pH of the reaction. Higher pH tends to drive the decay reaction towards Meta III. [61]
Dark adaptation of both rods and cones requires the regeneration of the visual pigment from opsin and 11-cis retinal. [13] Therefore, the time required for dark adaptation and pigment regeneration is largely determined by the local concentration of 11-cis retinal and the rate at which it is delivered to the opsin in the bleached rods. [14]
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