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The classical cannabinoids are concentrated in a viscous resin produced in structures known as glandular trichomes. At least 113 different cannabinoids have been isolated from the Cannabis plant. [6] All classes derive from cannabigerol-type (CBG) compounds and differ mainly in the way this precursor is cyclized. [21]
Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound. [10] Similar responses are produced when introduced in alternative methods, only in a more concentrated form than what is naturally occurring.
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [ 1 ] [ 2 ] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis .
3D model of 2-Arachidonoylglycerol, an endocannaboid. The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central nervous system (including the brain) and peripheral nervous system.
“The cannabinoid system is widespread in the brain, so modulating cannabinoid function with products like THC could have a wide range of possible effects. We wanted to better understand which ...
Differences in the chemical composition of Cannabis varieties may produce different effects in humans. Synthetic THC, called dronabinol, does not contain cannabidiol (CBD), cannabinol (CBN), or other cannabinoids, which is one reason why its pharmacological effects may differ significantly from those of natural Cannabis preparations.
Synthetic cannabinoids were made for cannabinoid research focusing on tetrahydrocannabinol (THC), cannabinoid receptors, and the endocannabinoids that activate them in the body. Synthetic cannabinoids were needed partly due to legal restrictions on natural cannabinoids, which make them difficult to obtain for research.