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Technetium (99m Tc) sestamibi (commonly sestamibi; USP: technetium Tc 99m sestamibi; trade name Cardiolite) is a pharmaceutical agent used in nuclear medicine imaging.The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands.
Nuclear medicine myocardial perfusion scan with thallium-201 for the rest images (bottom rows) and Tc-Sestamibi for the stress images (top rows). The nuclear medicine myocardial perfusion scan plays a pivotal role in the non-invasive evaluation of coronary artery disease. The study not only identifies patients with coronary artery disease; it ...
Myocardial perfusion imaging or scanning (also referred to as MPI or MPS) is a nuclear medicine procedure that illustrates the function of the heart muscle . [ 1 ] It evaluates many heart conditions, such as coronary artery disease (CAD), [ 2 ] hypertrophic cardiomyopathy and heart wall motion abnormalities.
The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small amounts as an agent in a nuclear medicine scan, during one type of nuclear cardiac stress test. Soluble thallium salts (many of which are nearly tasteless) are highly toxic and they were historically used in rat poisons and insecticides .
Scintigraphy (from Latin scintilla, "spark"), also known as a gamma scan, is a diagnostic test in nuclear medicine, where radioisotopes attached to drugs that travel to a specific organ or tissue (radiopharmaceuticals) are taken internally and the emitted gamma radiation is captured by gamma cameras, which are external detectors that form two-dimensional images [1] in a process similar to the ...
Projections are acquired at defined points during the rotation, typically every 3–6 degrees. In most cases, a full 360-degree rotation is used to obtain an optimal reconstruction. The time taken to obtain each projection is also variable, but 15–20 seconds is typical. This gives a total scan time of 15–20 minutes.
Thallium poisoning is poisoning that is due to thallium and its compounds, which are often highly toxic. [1] Contact with skin is dangerous and adequate ventilation should be provided when melting this metal. [2] Many thallium compounds are highly soluble in water and are readily absorbed through the skin. [3]
The element thallium, discovered by Crookes The mineral crookesite, a selenide of copper, thallium and silver (Cu 7 (Tl, Ag)Se 4), named for Crookes. His first important discovery was that of the element thallium, made with the help of flame spectroscopy. Crookes discovered a previously unknown element with a bright green emission line in its ...