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The histamine receptors are a class of G protein–coupled receptors which bind histamine as their primary endogenous ligand. [1] [2] Histamine receptors are proteins that bind with histamine, a neurotransmitter involved in various physiological processes. There are four main types: H1, H2, H3, and H4.
The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart, and in the central nervous system .
Histamine H 3 receptor: Located in the central nervous system and to a lesser extent peripheral nervous system tissue Autoreceptor and heteroreceptor functions: decreased neurotransmitter release of histamine, acetylcholine, norepinephrine, serotonin. Modulates nociception, gastric acid secretion, and food intake. [23] Histamine H 4 receptor
The gene sequence for H 3 receptors expresses only about 22% and 20% homology with both H 1 and H 2 receptors respectively. There is much interest in the histamine H 3 receptor as a potential therapeutic target because of its involvement in the neuronal mechanism behind many cognitive disorders and especially its location in the central nervous ...
Pages in category "Histamine receptors" The following 5 pages are in this category, out of 5 total. This list may not reflect recent changes. H. Histamine H1 receptor;
H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. [5] PKA functions to phosphorylate certain proteins, affecting their ...
59340 225192 Ensembl ENSG00000134489 ENSMUSG00000037346 UniProt Q9H3N8 Q91ZY2 RefSeq (mRNA) NM_001143828 NM_001160166 NM_021624 NM_153087 RefSeq (protein) NP_001137300 NP_001153638 NP_067637 NP_694727 Location (UCSC) Chr 18: 24.46 – 24.48 Mb Chr 18: 13.14 – 13.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The histamine H 4 receptor, like the other three histamine receptors ...
Histaminergic means "working on the histamine system", and histaminic means "related to histamine". [1] A histaminergic agent (or drug) is a chemical which functions to directly modulate the histamine system in the body or brain. Examples include histamine receptor agonists and histamine receptor antagonists (or antihistamines).