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Mebendazole (MBZ), sold under the brand name Vermox among others, is a medication used to treat a number of parasitic worm infestations. [5] This includes ascariasis , pinworm infection , hookworm infections , guinea worm infections and hydatid disease , among others. [ 5 ]
Benzimidazole is a base: . C 6 H 4 N(NH)CH + H + → [C 6 H 4 (NH) 2 CH] +. It can also be deprotonated with stronger bases: . C 6 H 4 N(NH)CH + LiH → Li [C 6 H 4 N 2 CH] + H 2. The imine can be alkylated and also serves as a ligand in coordination chemistry.
Pyrantel is a medication used to treat a number of parasitic worm infections. [2] This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. [2]
4‑Hydroxyacetamide (1) is alkylated with n-propyl bromide in the presence of potassium hydroxide to give the ether (2).Nitration of this product with nitric and sulfuric acids proceeds at the position ortho to the amide group (3), which is then reduced with SnCl 2 to yield the phenylenediamine derivative (4).
A 2008 review found that the efficacy of single-dose treatments for hookworm infections were as follows: 72% for albendazole, 15% for mebendazole, and 31% for pyrantel pamoate. [29] This substantiates prior claims that albendazole is much more effective than mebendazole for hookworm infections.
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
The signal is a short electrical pulse called action potential or 'spike'. Fig 2. Time course of neuronal action potential ("spike"). Note that the amplitude and the exact shape of the action potential can vary according to the exact experimental technique used for acquiring the signal.
Flubendazole is an anthelmintic, used both in humans and for veterinarian purposes. It is very close chemically to mebendazole , the only difference being an added fluorine atom. [ 2 ]