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How to detect and correct for systematic errors, especially in sciences where random errors are large (a situation Tukey termed uncomfortable science). The Graybill–Deal estimator is often used to estimate the common mean of two normal populations with unknown and possibly unequal variances.
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While precision is a description of random errors (a measure of statistical variability), accuracy has two different definitions: More commonly, a description of systematic errors (a measure of statistical bias of a given measure of central tendency, such as the mean). In this definition of "accuracy", the concept is independent of "precision ...
It is used primarily as a visual aid for detecting bias or systematic heterogeneity. A symmetric inverted funnel shape arises from a ‘well-behaved’ data set, in which publication bias is unlikely. An asymmetric funnel indicates a relationship between treatment effect estimate and study precision.
Any non-linear differentiable function, (,), of two variables, and , can be expanded as + +. If we take the variance on both sides and use the formula [11] for the variance of a linear combination of variables (+) = + + (,), then we obtain | | + | | +, where is the standard deviation of the function , is the standard deviation of , is the standard deviation of and = is the ...
Protein folding problem: Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will adopt a given structure under certain environmental conditions?
The statistical errors, on the other hand, are independent, and their sum within the random sample is almost surely not zero. One can standardize statistical errors (especially of a normal distribution ) in a z-score (or "standard score"), and standardize residuals in a t -statistic , or more generally studentized residuals .
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