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In genetics, a reciprocal cross is a breeding experiment designed to test the role of parental sex on a given inheritance pattern. [1] All parent organisms must be true breeding to properly carry out such an experiment. In one cross, a male expressing the trait of interest will be crossed with a female not expressing the trait.
The first uses of test crosses were in Gregor Mendel’s experiments in plant hybridization.While studying the inheritance of dominant and recessive traits in pea plants, he explains that the “signification” (now termed zygosity) of an individual for a dominant trait is determined by the expression patterns of the following generation.
His experimental method included repetitions and controls. He wanted to test if hybrids across species could be fertile. Buffon had used the idea of sterility of crosses as a method of testing species boundaries. Buffon used sterility versus fertility as a criterion for species but he gave up the idea in 1753 when he found fertile hybrids in ...
A diallel cross is a mating scheme used by plant and animal breeders, as well as geneticists, to investigate the genetic underpinnings of quantitative traits. [1] [2] In a full diallel, all parents are crossed to make hybrids in all possible combinations. Variations include half diallels with and without parents, omitting reciprocal crosses. [3]
The multitrait-multimethod (MTMM) matrix is an approach to examining construct validity developed by Campbell and Fiske (1959). [1] It organizes convergent and discriminant validity evidence for comparison of how a measure relates to other measures.
The T4 rII system is an experimental system developed in the 1950s by Seymour Benzer for studying the substructure of the gene. The experimental system is based on genetic crosses of different mutant strains of bacteriophage T4, a virus that infects the bacteria Escherichia coli.
The use of a sequence of experiments, where the design of each may depend on the results of previous experiments, including the possible decision to stop experimenting, is within the scope of sequential analysis, a field that was pioneered [12] by Abraham Wald in the context of sequential tests of statistical hypotheses. [13]
Crossover experiments allow for experimental study of a reaction mechanism. Mechanistic studies are of interest to theoretical and experimental chemists for a variety of reasons including prediction of stereochemical outcomes, optimization of reaction conditions for rate and selectivity, and design of improved catalysts for better turnover number, robustness, etc. [6] [7] Since a mechanism ...