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The primary manifestations are thrombocytopenia and megakaryocytopenia, i.e. low numbers of platelets and megakaryocytes. There is an absence of megakaryocytes in the bone marrow with no associated physical abnormalities. [14] The cause for this disorder appears to be a mutation in the gene for the TPO receptor, c-mpl, despite high levels of ...
Compared to megakaryoblasts, promegakaryocytes and granular megakaryocytes are both larger and contain less basophilic cytoplasm with granules. Promegakaryocytes are usually about 15μm to 30μm in diameter with a lobed nucleus and some azurophil granules within moderately basophilic cytoplasm.
The megakaryoblast is a platelet precursor that undergoes endomitosis to form megakaryocytes that have 8 to 64 nuclei. Megakaryocytes shed platelets into the bloodstream. β1-tubulin microtubules, which are found in megakaryocytes, facilitate this process of shedding platelets into the bloodstream. [5]
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
Steatopygia is the state of having substantial levels of tissue on the buttocks and thighs. This build is not confined to the gluteal regions, but extends to the outside and front of the thighs, and tapers to the knee producing a curvilinear figure.
Why gravity is weak and the cosmological constant is small [ edit ] Some versions of brane cosmology, based on the large extra dimension idea, can explain the weakness of gravity relative to the other fundamental forces of nature, thus solving the hierarchy problem .
To compare numbers in scientific notation, say 5×10 4 and 2×10 5, compare the exponents first, in this case 5 > 4, so 2×10 5 > 5×10 4. If the exponents are equal, the mantissa (or coefficient) should be compared, thus 5×10 4 > 2×10 4 because 5 > 2.
Conversely, if the more distant object did subtend the same angle as the nearer object then it is normally perceived to be twice as big. One question concerning the Moon illusion, therefore, is whether the horizon Moon appears larger because its perceived angular size seems greater, or because its perceived physical size seems greater, or some ...