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Chemokines (from Ancient Greek χῠμείᾱ (khumeíā) 'alchemy' and κῑ́νησῐς (kī́nēsis) 'movement'), or chemotactic cytokines, are a family of small cytokines or signaling proteins secreted by cells that induce directional movement of leukocytes, as well as other cell types, including endothelial and epithelial cells.
Cytokines (/ ˈ s aɪ t ə k aɪ n /) [1] are a broad and loose category of small proteins (~5–25 kDa [2]) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target
Cytokines in bovine colostrum enhance B and T cell maturation and increase endogenous antibody production. They also help regulate epithelial cell growth and development, proliferation, and restitution. Transfer factors enhance the activity of T cells. Other growth and immune factors such as IGF-1, IGF-2, FGF, EGF, TGF, PDGF, etc.
For immune cell differentiation, some reports show that CXCL9 lead to Th1 polarization through CXCR3. [17] In vivo model by Zohar et al. showed that CXCL9, drove increased transcription of T-bet and RORγ, leading to the polarization of Foxp3 − type 1 regulatory (Tr1) cells or T helper 17 (Th17) from naive T cells via STAT1, STAT4, and STAT5 phosphorylation.
In mammals, prolactin is associated with milk production; in fish it is thought to be related to the control of water and salt balance. Prolactin also acts in a cytokine-like manner and as an important regulator of the immune system. It has important cell cycle-related functions as a growth-, differentiating- and anti-apoptotic factor.
[11] [12] Miller and his co-workers (1954) isolated and purified the cell division substance in crystallised form from autoclaved herring fish sperm DNA. [11] This active compound was named as Kinetin because of its ability to promote cell division and was the first cytokinin to be named. Kinetin was later identified to be 6-furfuryl-amino purine.
The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses. The increased expression of chemokines attracts other cells including neutrophils but not eosinophils. IL-17 function is also essential to a subset of CD4+ T-Cells called T helper 17 (T h 17) cells.
Similarly to CD4 + T H cells, a third category called T C 17 were discovered that also secrete IL-17. As for the ILCs, they [Clarification needed.] may be classified into three main categories [5] ILC1 which secrete type 1 cytokines, ILC2 which secrete type 2 cytokines, ILC3 which secrete type 17 cytokines.