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Microfluidics devices also can simulate the tumor microenvironment, to help to test anticancer drugs. Microfluidic devices with 2D or 3D cell cultures can be used to analyze spheroids for different cancer systems (such as lung cancer and ovarian cancer), and are essential for multiple anti-cancer drugs and toxicity tests. This strategy can be ...
Microfluidic devices can be used for the synthesis of confined cholesteric liquid crystals through layering of multiple shell-like layers consisting of varying oil-in-water and water-in-oil emulsions. [169] The construction of encapsulated liquid crystals through microfluidic flow of liquid crystal droplets in an immiscible oil allows for ...
Electrowetting, dielectrophoresis, and immiscible-fluid flows are the three most commonly used principles, which have been used to generate and manipulate microdroplets in a digital microfluidic device. A digital microfluidic (DMF) device set-up depends on the substrates used, the electrodes, the configuration of those electrodes, the use of a ...
Although these devices have proven very useful, there are certain disadvantages such as cells sticking to the PDMS surface, small molecules diffusing into the PDMS, and unreacted PDMS polymers washing into cell culture media. [10] The use of 3D cell cultures in microfluidic devices has led to a field of study called organ-on-a-chip. The first ...
Devices have been made using platforms that range from traditional 2D cell culture to 3D tissues in the form of organotypic brain slices and more recently organoids. Organotypic brain slices are an in vitro model that replicates in vivo physiology with additional throughput and optical benefits, [8] thus pairing well with microfluidic devices ...
The main advantage of paper-based microfluidic devices over traditional microfluidics devices is their potential for use in the field rather than in a laboratory. [61] [62] Filter paper is advantageous in a field setting because it is capable of removing contaminants from the sample and preventing them from moving down the microchannel.
Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids. However, strictly regarded "lab-on-a-chip" indicates generally the scaling of single or multiple lab ...
Lab disk for protein structure analysis via small-angle X-ray scattering. The centrifugal micro-fluidic biochip or centrifugal micro-fluidic biodisk is a type of lab-on-a-chip technology, also known as lab-on-a-disc, that can be used to integrate processes such as separating, mixing, reaction and detecting molecules of nano-size in a single piece of platform, including a compact disk or DVD.