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Leukocyte esterase (LE) is an esterase (a type of enzyme) produced by leukocytes (white blood cells). A leukocyte esterase test (LE test) is a urine test for the presence of white blood cells and other abnormalities associated with infection. White blood cells in the urine can indicate a urinary tract infection (UTI). Positive test results may ...
Results that typically require microscopic examination include abnormal color or clarity and positive dipstick results for blood, leukocytes, nitrite, or protein. [ 90 ] If microscopy is necessary, the urine may be centrifuged to concentrate the solid elements so that they can be viewed more easily.
Reference ranges for urine tests are described below: Measurement Lower limit Upper limit Unit ... Leukocytes: n/a: 0 / negative [2] See also. Reference range;
The urine test strip reaction is based on the action of leukocyte esterase in catalysing the hydrolysis of an ester of indolecarboxylic acid. The indoxyl that is liberated combines with a diazonium salt in order to produce a violet coloured azole dye. [21] 1) Reaction catalysed by leukocyte esterase
In the elderly, the leukocyte esterase test is often positive even in the absence of an infection. [citation needed] The urine dipstick test is readily available and provides fast, but often unreliable results. Some organisms such as chlamydia and Ureaplasma urealyticum will produce a negative leukocyte esterase reaction.
A urine test is any medical test performed on a urine specimen. The analysis of urine is a valuable diagnostic tool because its composition reflects the functioning of many body systems, particularly the kidneys and urinary system , and specimens are easy to obtain. [ 1 ]
In complicated or questionable cases, it may be useful to confirm the diagnosis via urinalysis, looking for the presence of urinary nitrites, white blood cells (leukocytes), or leukocyte esterase. [54] Another test, urine microscopy, looks for the presence of red blood cells, white blood cells, or bacteria.
It has been arbitrarily assumed that a number of over 4-5 leukocytes in the field of vision of the microscope indicates leukocyturia. [4] At the moment, there are also quick test strips available, allowing after wetting a special diagnostic bar, the detection of granulocytes in the urine, as evidenced by the color change of the test strip. [5]