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Quetiapine may not differ from typical antipsychotics in the treatment of positive symptoms, general psychopathology, and negative symptoms. However, it causes fewer adverse effects in terms of abnormal ECG , extrapyramidal effects, abnormal prolactin levels and weight gain.
Since it is difficult to measure extrapyramidal symptoms, rating scales are commonly used to assess the severity of movement disorders. The Simpson-Angus Scale (SAS), Barnes Akathisia Rating Scale (BARS), Abnormal Involuntary Movement Scale (AIMS), and Extrapyramidal Symptom Rating Scale (ESRS) are rating scales frequently used for such assessment and are not weighted for diagnostic purposes ...
Both clozapine and quetiapine appear to bind just long enough to elicit antipsychotic effects but not long enough to induce extrapyramidal side effects and prolactin hypersecretion. [ 175 ] 5-HT 2A antagonism increases dopaminergic activity in the nigrostriatal pathway , leading to a lowered extrapyramidal side effect liability among the ...
Quetiapine binds D 1, D 2 and D 3 and can bind D 4 at high concentrations. [2] It is used to treat the positive symptoms of schizophrenia, [13] bipolar disorder and depression. [1] Of the second generation antipsychotics, quetiapine may produce fewer parkinsonian side effects. [24] Paliperidone binds D 2, D 3 and D 4 with high affinity; can ...
The atypical antipsychotics (AAP), also known as second generation antipsychotics (SGAs) and serotonin–dopamine antagonists (SDAs), [1] [2] are a group of antipsychotic drugs (antipsychotic drugs in general are also known as tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) largely introduced after the 1970s and used to treat psychiatric ...
Both generations of medication tend to block receptors in the brain's dopamine pathways, but atypicals at the time of marketing were claimed to differ from typical antipsychotics in that they are less likely to cause extrapyramidal symptoms (EPS), which include unsteady Parkinson's disease-type movements, internal restlessness, and other ...
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