Search results
Results From The WOW.Com Content Network
The two main components of the gel are mucins and water, with the mucins forming the backbone of the mucous. [4] Mucin originates from the mucus secretions from submaxillary glands, which are salivary glands that are located under the floor of the mouth. The secreted mucin assists in digestion by coating the bolus such that it travels easily ...
Mucins (/ ˈ m juː s ɪ n /) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. [1] Mucins' key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. [1]
The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic properties. [7] [4] MUC5AC is the main gel-forming mucin secreted by goblet cells, in the form of threads and thin sheets. MUC5B is a polymeric protein secreted from submucosal glands and some goblet cells, and this is in the ...
74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in the mouse. It is one of the five gel ...
17831 Ensembl ENSG00000198788 ENSMUSG00000025515 UniProt Q02817 n/a RefSeq (mRNA) NM_002457 NM_023566 RefSeq (protein) NP_002448 n/a Location (UCSC) Chr 11: 1.07 – 1.11 Mb Chr 7: 141.28 – 141.31 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin 2, oligomeric mucus gel-forming, also known as MUC2, is a protein that in humans is encoded by the MUC2 gene. Function This gene ...
Goblet cells are simple columnar epithelial cells that secrete gel-forming mucins, like mucin 2 in the lower gastrointestinal tract, and mucin 5AC in the respiratory tract. [1] The goblet cells mainly use the merocrine method of secretion, secreting vesicles into a duct, but may use apocrine methods, budding off their secretions, when under ...
These are known as non-ciliated columnar epithelium. Non-ciliated simple columnar epithelium is made up of glandular goblet cells which secrete mucin to form mucus. [1] The rest of the cell is made up of cytoplasm with membrane bound secretory granules which secrete the mucin, and are found towards the apical surface of the cell. [1]
Consistency and viscosity affect the adhesion and retention property of the gel, and are important in ensuring the gel is retained at the site of application and effective delivery of the drug. [3] The ingredients in topical gel formulation can be broadly categorized into four types: gelator, solvent, drug, and excipients.