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Mucin genes encode mucin monomers that are synthesized as rod-shaped apomucin cores that are post-translationally modified by exceptionally abundant glycosylation. The dense "sugar coating" of mucins gives them considerable water-holding capacity and also makes them resistant to proteolysis , which may be important in maintaining mucosal barriers.
Mucin-4 (MUC-4) is a mucin protein that in humans is encoded by the MUC4 gene. [3] Like other mucins, MUC-4 is a high-molecular weight glycoprotein. [4]The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins.
74180 Ensembl ENSG00000117983 ENSMUSG00000066108 UniProt Q9HC84 n/a RefSeq (mRNA) NM_002458 NM_028801 RefSeq (protein) NP_002449 n/a Location (UCSC) Chr 11: 1.22 – 1.26 Mb Chr 7: 141.39 – 141.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Mucin-5B (MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by the Muc5b gene in the mouse. It is one of the five gel ...
Mucin 16 is a membrane associated mucin that possesses a single transmembrane domain. [9] A unique property of MUC16 is its large size. MUC16 is more than twice as long as MUC1 and MUC4 and contains about 22,000 amino acids, making it the largest membrane-associated mucin. [10] MUC16 is composed of three different domains: [11] An N-terminal domain
Mucin-1 (MUC-1) is a heterodimer transmembrane protein of the mucin family encoded in humans by the MUC1 gene. [3] [4] [5] It is cleaved into two chains: mucin-1 ...
Mucin short variant S1, also called polymorphic epithelial mucin (PEM) or epithelial membrane antigen (EMA), is a mucin encoded by the MUC1 gene in humans. [3] Mucin short variant S1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain.
Mucin-5AC (MUC-5AC) is a protein that is encoded by the MUC5AC gene in humans. [5] [6] [7]MUC-5AC is a large gel-forming glycoprotein.In the respiratory tract, it protects against infection by binding to inhaled pathogens, which are subsequently removed by mucociliary clearance.
Mucus is made up of a fluid component of around 95% water, the mucin secretions from the goblet cells, and the submucosal glands (2–3% glycoproteins), proteoglycans (0.1–0.5%), lipids (0.3–0.5%), proteins, and DNA. [7] The major mucins secreted – MUC5AC and MUC5B - are large polymers that give the mucus its rheologic or viscoelastic ...