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John S. Sappington (1776-1856) was an American physician known for developing a quinine pill to treat malarial and other fever diseases in the Missouri and Mississippi valleys, where the disease was widespread. He later used the pill to prevent malaria.
John Sappington (1776–1856) was a prominent early physician and businessman in Missouri. He was a proponent of using quinine in the treatment of malaria and was at the time the largest importer of the drug in the United States. [4] Sappington also wrote the first medical book published west of the Mississippi River. [5]
Quinine is a medication used to treat malaria and babesiosis. [5] ... Sappington developed a pill to treat a variety of fevers, such as scarlet fever, yellow fever ...
Claiborne Fox Jackson (April 4, 1806 – December 6, 1862) was an American politician of the Democratic Party in Missouri. He was elected as the 15th Governor of Missouri, serving from January 3, 1861, until July 31, 1861, when he was forced out by the Unionist majority in the Missouri General Assembly after planning to force the secession of the state.
In 1826, Marmaduke married Lavinia Sappington, the daughter of Dr. John and Jane Sappington. Her father became a prominent pioneer physician of Saline County, who was later known for his development of a patent medicine, a quinine pill used to treat malaria and other fevers. He manufactured "fever pills" that incorporated quinine and sold them ...
Jesuit's bark, also known as cinchona bark, Peruvian bark or China bark, is a former remedy for malaria, as the bark contains quinine used to treat the disease. [1] The bark of several species of the genus Cinchona , family Rubiaceae indigenous to the western Andes of South America, was introduced to Jesuit missionaries during the 17th century ...
Quinine remained the first-line antimalarial drug of choice until the 1940s, when other drugs replaced it. Until recently Chloroquine was the most widely used antimalarial drug. [ citation needed ] Warburg's Tincture was included in Burroughs Wellcome & Company 's tabloid medicine cases of the late 19th and early 20th centuries.
The subject has also been attended with some controversy: Gilbert Stork published the first stereoselective total synthesis of quinine in 2001, meanwhile shedding doubt on the earlier claim by Robert Burns Woodward and William Doering in 1944, claiming that the final steps required to convert their last synthetic intermediate, quinotoxine, into ...