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To identify an saRNA that can activate a gene of interest, several saRNAs need to be designed within a 1- to 2-kbp promoter region by following a set of rules [3] [4] and tested in cultured cells. In some reports, saRNAs are designed in such a way to target non-coding transcripts that overlap the promoter sequence of a protein coding gene.
Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising tool for vaccines and other therapeutic applications. As a "next-generation" mRNA, saRNA is designed to achieve ...
Demodicosis / ˌ d ɛ m ə d ə ˈ k oʊ s ɪ s /, also called Demodex folliculitis in humans [1] and demodectic mange (/ d ɛ m ə ˈ d ɛ k t ɪ k /) or red mange in animals, is caused by a sensitivity to and overpopulation of Demodex spp. as the host's immune system is unable to keep the mites under control.
Mange (/ ˈ m eɪ n dʒ /) is a type of skin disease caused by parasitic mites. [1] Because various species of mites also infect plants, birds and reptiles, the term "mange", or colloquially "the mange", suggesting poor condition of the skin and fur due to the infection, is sometimes reserved for pathological mite-infestation of nonhuman mammals.
Animals including dogs and cats can also be affected by ringworm, and the disease can be transmitted between animals and humans, making it a zoonotic disease. Specific signs can be: red, scaly, itchy or raised patches; patches may be redder on outside edges or resemble a ring; patches that begin to ooze or develop a blister
Sarcoptes scabiei (/sɑːrˈkɒptiːz skeɪˈbiːaɪ/ Traditional English pronunciation of Latin) or the itch mite is a parasitic mite found in all parts of the world that burrows into skin and causes scabies.
A dog displaying a typical clinical picture of visceral leishmaniasis. Canine leishmaniasis (LEESH-ma-NIGH-ah-sis) is a zoonotic disease (see human leishmaniasis) caused by Leishmania parasites transmitted by the bite of an infected phlebotomine sandfly. There have been no documented cases of leishmaniasis transmission from dogs to humans.
Canine coronavirus (CCoV) is an enveloped, positive-sense, single-stranded RNA virus which is a member of the species Alphacoronavirus 1. It causes a highly contagious intestinal disease worldwide in dogs. [2]