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Linaclotide, (sold under the brand name Linzess in the US and Mexico, and as Constella elsewhere) [6] is a drug used to treat irritable bowel syndrome with constipation and chronic constipation with no known cause.
As plecanatide acts on receptors present on the apical side of endothelial cells lining the gastrointestinal tract it is able to impart its effect without ever entering circulation. [13] As with most orally ingested peptides, plecanatide is degraded by intestinal enzymes, and so very little of the active drug enters systemic circulation. [ 12 ]
Eluxadoline is a μ-and κ-opioid receptor agonist and δ-opioid receptor antagonist [12] that acts locally in the enteric nervous system, possibly decreasing adverse effects on the central nervous system. [13] [14]
A review that considered berberine’s effects on heart health found some studies supporting this claim, but due to the high risk of bias, the researchers recommended more clinical trials be ...
Cialis has several common side effects, many of which also happen with other drugs used to treat ED, like sildenafil (generic Viagra®), vardenafil , and avanafil (Stendra®).
Hyoscyamine (also known as daturine or duboisine) is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane, mandrake, angel's trumpets, jimsonweed, the sorcerers' tree, and Atropa belladonna (deadly nightshade).
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