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Conditions of the human integumentary system constitute a broad spectrum of diseases, also known as dermatoses, as well as many nonpathologic states (like, in certain circumstances, melanonychia and racquet nails).
Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the body and composed of skin, hair, nails, and related muscle and glands. [1] The major function of this system is as a barrier against the external environment. [2]
Cutaneous conditions caused by mutations in structural proteins within the epidermis, excluding keratin proteins Defective protein Conditions(s) Loricrin: Vohwinkel syndrome [nb 1] Progressive symmetric erythrokeratodermia: Filaggrin: Ichthyosis vulgaris Atopic dermatitis
List of immunofluorescence findings for autoimmune bullous conditions; List of inclusion bodies that aid in diagnosis of cutaneous conditions; List of keratins expressed in the human integumentary system; List of radiographic findings associated with cutaneous conditions; List of specialized glands within the human integumentary system
Dermatoepidemiology is the study of skin disease at the population level. [43] One of its aspects is the determination of the global burden of skin diseases. [44] [45] From 1990 to 2013, skin disease constituted about 2% of total global disease disability [46] as measured in disability-adjusted life-years. [47]
Sunspots are small darkened areas on the skin, often on the face. Top derms explain the causes, ways to treat them and when to worry about skin cancer.
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Conditions caused by mutations in or antibodies against junctional proteins found within the epidermis of the human integumentary system. Junctional protein Condition(s) Desmocollin 1: Subcorneal pustular dermatosis type of IgA pemphigus: Desmocollin 2: Arrhythmogenic right ventricular dysplasia (ARVD) Desmoglein 1: Striate palmoplantar keratoderma