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Metallosis is the medical condition involving deposition and build-up of metal debris in the soft tissues of the body. [1]Metallosis has been known to occur when metallic components in medical implants, specifically joint replacements, abrade against one another. [1]
There are reports of cobalt toxicity with hip replacement, particularly metal-on-metal hip replacements, which are no longer in use. [49] [50] Use of metal-on-metal hip replacements from the 1970s was discontinued in the 1980s and 1990s, particularly after the discovery of aseptic lymphocyte-dominant vasculitis-associated lesions (ALVAL).
Many metals, particularly heavy metals are toxic, but some are essential, and some, such as bismuth, have a low toxicity. Metals in an oxidation state abnormal to the body may also become toxic: chromium(III) is an essential trace element, but chromium(VI) is a carcinogen. Only soluble metal-containing compounds are toxic. Soluble metals are ...
PJIs are the most common cause of knee replacement failures, and the third most common cause of hip replacement failures. [1] As of 2017, 2.1% of hip and 2.3% of knee replacements will at some time develop a PJI. [2] The incidence of PJIs have more than tripled in the last 20 years, with the incidence expected to further increase in the future.
New diabetes and weight-loss drugs may benefit patients undergoing hip replacement, without adding to complication risks, according to preliminary data released on Monday at a large meeting of ...
Medical Device Alert: DePuy ASR TM acetabular cups used in hip resurfacing arthroplasty and total hip replacement, Medicines and Healthcare products Regulatory Agency, MDA/2010/044, 25 May 2010; Medical Device Alert: All metal-on-metal (MoM) hip replacements, Medicines and Healthcare products Regulatory Agency, MDA/2012/008, 28 February 2012
Cobalt poisoning is intoxication caused by excessive levels of cobalt in the body. Cobalt is an essential element for health in animals in minute amounts as a component of vitamin B 12 . A deficiency of cobalt, which is very rare, is also potentially lethal, leading to pernicious anemia .
Other techniques, such as metal-on-metal resurfacing, may not be suitable in all cases of avascular necrosis; its suitability depends on how much damage has occurred to the femoral head. [23] Bisphosphonates, which reduce the rate of bone breakdown, may prevent collapse (specifically of the hip) due to AVN. [24]