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The following bones develop in humans via Intramembranous ossification: [3] Flat bones of the face; Most of the bones of the skull; Clavicles; Other bone that formed by intramembranous ossification are: cortices of tubular and flat bones as well as the calvaria, upper facial bones, tympanic temporal bone, vomer, and medial pterygoid process. [4]
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
In contrast, intramembranous ossification takes place directly beneath the periosteum, adjacent to the broken bone’s ends. [10] [12] A schematic of endochondral fracture, where B shows the location of both endochondral and intramembranous ossification.
Intramembranous ossification is the direct ossification of mesenchyme as happens during the formation of the membrane bones of the skull and others. [8] During osteoblast differentiation, the developing progenitor cells express the regulatory transcription factor Cbfa1/Runx2. A second required transcription factor is Sp7 transcription factor. [9]
Osseointegration is also defined as: "the formation of a direct interface between an implant and bone, without intervening soft tissue". [1]An osseointegrated implant is a type of implant defined as "an endosteal implant containing pores into which osteoblasts and supporting connective tissue can migrate". [2]
The periosteum is a membrane that covers the outer surface of all bones, [1] except at the articular surfaces (i.e. the parts within a joint space) of long bones. (At the joints of long bones the bone's outer surface is lined with "articular cartilage", a type of hyaline cartilage.)
The posterior fontanelles ossify within 6–8 weeks after birth. This is called intramembranous ossification. The mesenchymal connective tissue turns into bone tissue. Anterior fontanelle is a diamond-shaped membrane-filled space located between the two frontal and two parietal bones of the developing fetal skull. It persists until ...
Functional magnetic resonance imaging (fMRI) was employed to determine areas of activation in the cerebellar cortex in humans during a series of motor tasks. The activation areas for movements of lips, tongue, hands, and feet were determined and found to be sharply confined to lobules and sublobules and their sagittal zones in the rostral and caudal spinocerebellar cortex.