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Valve interstitial cells (VIC), cardiac valve interstitial cells, or also known as valvular interstitial cells (VICs), are the most prevalent cells in the heart valve leaflets, which are a type of mesenchymal stem cells (MSCs) and are responsible for maintaining the extracellular matrix that provides the mechanical properties of the heart valve.
Interstitial fibrosis, which is unspecific, and has been described in congestive heart failure, hypertension, and normal aging. [2] Subepicardial fibrosis, also unspecific, and is associated with non-infarction diagnoses such as myocarditis and non-ischemic cardiomyopathy. [3] [4] Replacement fibrosis, which indicates an older infarction. [2]
Mutations in the intercalated disc gene are responsible for various cardiomyopathies that can lead to heart failure. [2] Ruptured intercalated discs, in this case regarded as a visual artifact. Ruptured intercalated discs, when seen on histopathology, have two main causes: Microtome sectioning, thereby being a visual artifact. [4]
Heart disease is a type of cardiovascular disease that affects the heart’s structure and function. Several different heart conditions fall under the umbrella term for heart disease.
The composition and chemical properties of the interstitial fluid vary among organs and undergo changes in chemical composition during normal function, as well as during body growth, conditions of inflammation, and development of diseases, [2] as in heart failure [5] and chronic kidney disease. [6]
Cardiac physiology or heart function is the study of healthy, unimpaired function of the heart: involving blood flow; myocardium structure; the electrical conduction system of the heart; the cardiac cycle and cardiac output and how these interact and depend on one another.
The chordae tendineae (sg.: chorda tendinea) or tendinous cords, colloquially known as the heart strings, are inelastic cords of fibrous connective tissue that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart.
The American Heart Association recommends limiting your saturated fat to less than 6% of your total calories because saturated fat increases "bad" cholesterol and increases risk of heart disease.