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Elagolix is used in the treatment of moderate to severe pain associated with endometriosis in premenopausal women. [1] Endometriosis is a condition in which the endometrium, the inner lining of the uterus, grows outside of the uterus into surrounding tissues and causes symptoms such as pelvic pain and infertility. [13]
Unlike most other GnRH modulators, but similarly to elagolix (brand name Orilissa), relugolix is a non-peptide, small-molecule compound and is orally active. [ 8 ] [ 9 ] [ 10 ] It suppresses sex hormone levels to the postmenopausal or castrate range in both women and men.
Orilissa: GnRH antagonist: Oral: 150mg/day or 200mg twice/day Medroxyprogesterone acetate [c] Provera [b] Progestin: Oral: 5–10mg/day Depo-Provera [b] Progestin: IM: 150mg every 3 months Depo-SubQ Provera 104: Progestin: SC: 104mg every 3 months Lynestrenol [c] Orgametril [b] Progestin: Oral: 5–10mg/day Finasteride [d] Propecia [b] 5αR ...
Drug agencies have issued warnings regarding this phenomenon in the prescribing information for GnRH agonists. As testosterone surge does not occur with GnRH antagonists, there is no need for patients to receive an antiandrogen as flare protection during prostate cancer treatment. GnRH agonists also induce an increase in testosterone levels ...
The Army on Saturday identified the third soldier on the Black Hawk helicopter involved in the midair crash over the Potomac River as Capt. Rebecca M. Lobach. Lobach, of Durham, North Carolina ...
Roads were still closed Thursday morning after a historic winter storm hit the South, bringing inches of snow to areas not used to seeing any snowfall at all. Drivers in southeastern Louisiana ...
Orilissa: GnRH antagonist: Oral: 150 mg/day or 200 mg twice daily Finasteride: Propecia: 5αR inhibitor: Oral: 1–5 mg/day Dutasteride: Avodart: 5αR inhibitor: Oral: 0.25–0.5 mg/day Progesterone: Prometrium [c] Progestogen: Oral: 100–400 mg/day Medroxyprogesterone acetate: Provera: Progestogen: Oral: 2.5–40 mg/day Depo-Provera ...
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