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Zavegepant is a calcitonin gene-related peptide receptor antagonist. [1] It is sprayed into the nose. [1] It is sold by Pfizer. [1] The most common adverse reactions include taste disorders, nausea, nasal discomfort, and vomiting. [1] Zavegepant was approved for medical use in the United States in March 2023. [1] [2] [3] [4]
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). [ 1 ] Several monoclonal antibodies that bind to the CGRP receptor or peptide have been approved for prevention of migraine. [ 2 ]
Xylometazoline, also spelled xylomethazoline, is a medication used to reduce symptoms of nasal congestion, allergic rhinitis, and sinusitis. [2] It is used directly in the nose as a spray or drops. [3] Side effects include trouble sleeping, irritation of the nose, nausea, nosebleed (3%), period pain (10%) and headache (3%).
ATC code R01 Nasal preparations is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. [1] [2] [3] Subgroup R01 is part of the anatomical group R Respiratory system. [4]
Decongestant nasal sprays are advised for short-term use only, preferably 5 to 7 days at maximum. Some doctors advise to use them 3 days at maximum. A recent clinical trial has shown that a corticosteroid nasal spray may be useful in reversing this condition. [3] Topical nasal decongestants include: Oxymetazoline; Phenylephrine; Xylometazoline
Salmon calcitonin (sCT) [1] is the type of calcitonin hormone found in salmon. [ 2 ] Similar to humans, salmon calcitonin is a peptide hormone produced in the ultimobranchial region by parafollicular cells in response to hypercalcemia and lowers blood calcium and phosphate by promoting renal excretion.
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Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]