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Lubiprostone is a bicyclic fatty acid [15] derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements.
Lubiprostone, a derivative of prostaglandin E1, is also used as a medication. [2] [3] Prostaglandin E 1 is a vasodilator. It has various effects in the body that include opening blood vessels, relaxing smooth muscle, inhibiting clotting, and causing uterine contractions. [2] [4]
Lubiprostone is a gastrointestinal agent used for the treatment of constipation-predominant IBS. ... Since this action is not mediated by the autonomic nervous system
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Selexipag, sold under the brand name Uptravi, is a medication developed by Actelion for the treatment of pulmonary arterial hypertension (PAH). [3] [4] Selexipag and its active metabolite, ACT-333679 (or MRE-269, the free carboxylic acid), are agonists of the prostacyclin receptor, which leads to vasodilation in the pulmonary circulation. [5]
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Prucalopride is contraindicated where there is hypersensitivity to the active substance or to any of the excipients, renal impairment requiring dialysis, intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease, and ulcerative colitis and toxic megacolon ...
Top Trump officials fanned out this past week to talk to markets about the upside of Elon Musk’s activities as questions mounted about his team’s access to a sensitive payments system.