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Frequency. 1 in 5,000–10,000 [ 4 ] Marfan syndrome (MFS) is a multi-systemic genetic disorder that affects the connective tissue. [ 6 ][ 7 ][ 1 ] Those with the condition tend to be tall and thin, with long arms, legs, fingers, and toes. [ 1 ] They also typically have exceptionally flexible joints and abnormally curved spines. [ 1 ]
See media help. Valvular heart disease is any cardiovascular disease process involving one or more of the four valves of the heart (the aortic and mitral valves on the left side of heart and the pulmonic and tricuspid valves on the right side of heart). These conditions occur largely as a consequence of aging, [1] but may also be the result of ...
Aortic regurgitation (AR), also known as aortic insufficiency (AI), is the leaking of the aortic valve of the heart that causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. As a consequence, the cardiac muscle is forced to work harder than normal. [ 4 ]
Aortic stenosis is most commonly caused by age-related progressive calcific aortic valve disease (CAVD) (>50% of cases), with a mean age of 65 to 70 years. CAVD is the build-up of calcium on the cusps of the valve, and this calcification causes hardening and stenosis of the valve. [ 22 ]
It is one of the two most common valvular heart diseases in the elderly, [27] and the commonest type of valvular heart disease in low and middle income countries. [ 3 ] In a study of 595 male elite football players aged 18–38 and 47 sedentary non-athletes, mitral regurgitation was found in 20% football players and 15% in control group.
29.16% (from 48 to 62 per 100,000) and 22.7% (from 3.7 to 4.54 per 100,000) from 2007 to 2014. Heyde's syndrome is a syndrome of gastrointestinal bleeding from angiodysplasia in the presence of aortic stenosis. [1][2] It is named after Edward C. Heyde, MD, who first noted the association in 1958. [3] It is caused by cleavage of Von Willebrand ...
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