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Splenomegaly is an enlargement of the spleen. [1] The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen.Splenomegaly is one of the four cardinal signs of hypersplenism which include: some reduction in number of circulating blood cells affecting granulocytes, erythrocytes or platelets in any combination; a compensatory proliferative response in the bone marrow; and the ...
The spleen is enlarged in a variety of conditions such as malaria, mononucleosis and most commonly in cancers of the lymphatics, such as lymphomas or leukemia. It is removed under the following circumstances: When it becomes very large such that it becomes destructive to platelets/red blood cells or rupture is imminent; For diagnosing certain ...
Fever is the most common symptom of splenic abscess, followed by abdominal pain and a tender mass on palpation of the left upper quadrant of the abdomen. The common signs and symptoms described of a splenic abscess include the triad of fever, left upper quadrant tenderness, and leukocytosis is present only in one-third of the cases.
The presence of an enlarged spleen, and swollen posterior cervical, axillary, and inguinal lymph nodes are the most useful to suspect a diagnosis of infectious mononucleosis. On the other hand, the absence of swollen cervical lymph nodes and fatigue are the most useful to dismiss the idea of infectious mononucleosis as the correct diagnosis.
Splenic infarction is a condition in which blood flow supply to the spleen is compromised, [1] leading to partial or complete infarction (tissue death due to oxygen shortage) in the organ. [2] Splenic infarction occurs when the splenic artery or one of its branches are occluded, for example by a blood clot. [3]
If an individual's spleen is enlarged, as is frequent in mononucleosis, most physicians will advise against activities (such as contact sports) where injury to the abdomen could be catastrophic. [10] Patients whose spleens have been removed via a splenectomy must receive immunizations to help prevent infections such as pneumonia. This helps to ...
Enlarged liver and grossly enlarged spleen (together hepatosplenomegaly) are common; [3] the spleen can rupture and cause additional complications. Skeletal weakness and bone disease may be extensive. [3] Spleen enlargement and bone marrow replacement cause anemia, thrombocytopenia, and leukopenia.
Signs (including enlarged liver and spleen) and symptoms (including headache and vomiting) of acute HIV infection Signs and symptoms are diagnostic indications of an illness , injury, or condition. Signs are objective and externally observable; symptoms are a person's reported subjective experiences.