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  2. Lipid peroxidation - Wikipedia

    en.wikipedia.org/wiki/Lipid_peroxidation

    Lipid peroxidation, or lipid oxidation, is a complex chemical process that leads to oxidative degradation of lipids, [1] resulting in the formation of peroxide and hydroperoxide derivatives. [2] It occurs when free radicals , specifically reactive oxygen species (ROS), interact with lipids within cell membranes , typically polyunsaturated fatty ...

  3. Chain reactions in living organisms - Wikipedia

    en.wikipedia.org/wiki/Chain_reactions_in_living...

    Chain reaction in chemistry and physics is a process that produces products capable of initiating subsequent processes of a similar nature. It is a self-sustaining sequence in which the resulting products continue to propagate further reactions. [1] Examples of chain reactions in living organisms are lipid peroxidation in cell membranes [2] and ...

  4. Isotope effect on lipid peroxidation - Wikipedia

    en.wikipedia.org/wiki/Isotope_effect_on_lipid...

    Mechanism of isotope effect on lipid peroxidation. An animated model of a chain reaction with slow, oxidation-resistant elements. PUFAs are highly prone to oxidative damage through a purely chemical, non-enzymatic chain reaction. With tight packaging of PUFAs in membranes, the oxidation of a single PUFA molecule rapidly leads to a chain ...

  5. Oxidative stress - Wikipedia

    en.wikipedia.org/wiki/Oxidative_stress

    These metals are thought to induce Fenton reactions and the Haber-Weiss reaction, in which hydroxyl radical is generated from hydrogen peroxide. [76] The hydroxyl radical then can modify amino acids. For example, meta-tyrosine and ortho-tyrosine form by hydroxylation of phenylalanine. Other reactions include lipid peroxidation and oxidation of ...

  6. Lipid - Wikipedia

    en.wikipedia.org/wiki/Lipid

    The major sphingoid base of mammals is commonly referred to as sphingosine. Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide -linked fatty acid. The fatty acids are typically saturated or mono-unsaturated with chain lengths from 16 to 26 carbon atoms. [ 25 ]: 421–2.

  7. Ferroptosis - Wikipedia

    en.wikipedia.org/wiki/Ferroptosis

    Ferroptosis. Appearance. Oxytosis/ferroptosis is a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides, and is genetically and biochemically distinct from other forms of regulated cell death such as apoptosis. [ 1 ][ 2 ] Oxytosis/ferroptosis is initiated by the failure of the glutathione ...

  8. Lipid metabolism - Wikipedia

    en.wikipedia.org/wiki/Lipid_metabolism

    Lipid metabolism. Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown and storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. In animals, these fats are obtained from food and are synthesized by the liver. [1]

  9. 4-Hydroxynonenal - Wikipedia

    en.wikipedia.org/wiki/4-Hydroxynonenal

    Infobox references. 4-Hydroxynonenal, or 4-hydroxy-2E-nonenal or 4-hydroxy-2-nonenal or 4-HNE or HNE, (C 9 H 16 O 2), is an α,β-unsaturated hydroxyalkenal that is produced by lipid peroxidation in cells. 4-HNE is the primary α,β-unsaturated hydroxyalkenal formed in this process. It is a colorless oil.