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Malate dehydrogenase (EC 1.1.1.37) (MDH) is an enzyme that reversibly catalyzes the oxidation of malate to oxaloacetate using the reduction of NAD + to NADH. This reaction is part of many metabolic pathways , including the citric acid cycle .
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria.
In enzymology, a malate dehydrogenase (NADP +) (EC 1.1.1.82) is an enzyme that catalyzes the chemical reaction (S)-malate + NADP + oxaloacetate + NADPH + H +. Thus, the two substrates of this enzyme are (S)-malate and NADP +, whereas its 3 products are oxaloacetate, NADPH, and H +.
Malate dehydrogenase, mitochondrial also known as malate dehydrogenase 2 is an enzyme that in humans is encoded by the MDH2 gene. [5]Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle.
After malate reaches the mitochondrial matrix, it is converted by mitochondrial malate dehydrogenase into oxaloacetate, during which NAD + is reduced with two electrons to form NADH. Oxaloacetate is then transformed into aspartate (since oxaloacetate cannot be transported into the cytosol) by mitochondrial aspartate aminotransferase.
The systematic name of this enzyme class is (S)-malate:NADP + oxidoreductase (oxaloacetate-decarboxylating). This enzyme participates in pyruvate metabolism and carbon fixation . NADP-malic enzyme is one of three decarboxylation enzymes used in the inorganic carbon concentrating mechanisms of C4 and CAM plants.
Malate dehydrogenase (decarboxylating) (EC 1.1.1.39) or NAD-malic enzyme (NAD-ME) is an enzyme that catalyzes the chemical reaction (S)-malate + NAD + pyruvate + CO 2 + NADH. Thus, the two substrates of this enzyme are (S)-malate and NAD +, whereas its three products are pyruvate, CO 2, and NADH.
Malate dehydrogenase (NAD(P) +) (EC 1.1.1.299, MdH II, NAD(P) +-dependent malate dehyrogenase) is an enzyme with systematic name (S)-malate:NAD(P) + oxidoreductase. [1] This enzyme catalyses the following chemical reaction