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Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. [2] The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to ...
The antioxidant enzyme glutathione peroxidase 4 (GPX4) belongs to the family of glutathione peroxidases, which consists of 8 known mammalian isoenzymes (GPX1–8).GPX4 catalyzes the reduction of hydrogen peroxide, organic hydroperoxides, and lipid peroxides at the expense of reduced glutathione and functions in the protection of cells against oxidative stress.
Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene. [5] [6] [7]This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract.
Among the many metabolic processes in which it participates, glutathione is required for the biosynthesis of leukotrienes and prostaglandins. It plays a role in the storage of cysteine. Glutathione enhances the function of citrulline as part of the nitric oxide cycle. [24] It is a cofactor and acts on glutathione peroxidase. [25]
Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. [5] This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide , and is one of the most important antioxidant enzymes in humans.
2878 14778 Ensembl ENSG00000211445 ENSMUSG00000018339 UniProt P22352 P46412 RefSeq (mRNA) NM_002084 NM_001329790 NM_001083929 NM_008161 NM_001329860 RefSeq (protein) NP_001316719 NP_002075 NP_001316789 NP_032187 Location (UCSC) Chr 5: 151.02 – 151.03 Mb Chr 11: 54.79 – 54.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 3 (GPx-3), also known as plasma ...
Glutathione Peroxidase 1 (Peroxidases or peroxide reductases (EC number 1.11.1.x) are a large group of enzymes which play a role in various biological processes. They are named after the fact that they commonly break up peroxides, and should not be confused with other enzymes that produce peroxide, which are often oxidases.
75512 Ensembl ENSG00000281185 ENSG00000198704 ENSMUSG00000004341 UniProt P59796 Q91WR8 RefSeq (mRNA) NM_182701 NM_145451 RefSeq (protein) NP_874360 NP_663426 Location (UCSC) Chr 6: 28.5 – 28.53 Mb Chr 13: 21.5 – 21.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene. This gene product belongs ...