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Melanizing agents are drugs that increase sensitivity to solar radiation and promote re-pigmentation of de-pigmented areas of skin. Furocoumarins stimulate melanocytes and induce their proliferation on activation by light. Melanizing agents sensitize the skin to sunlight. As a result, erythema, inflammation and pigmentation occurs.
Accumulation of melanin, the skin pigment; Accumulation of drug or one of its products under any layer of the skin (usually the dermis or epidermis) Accumulation of iron throughout the dermis from drug-induced post-inflammatory changes; The synthesis of special pigments, under direct influence of the drug
Postinflammatory hyperpigmentation (PIH) is a skin condition characterized by the darkening of the skin (hyperpigmentation) following an inflammatory injury, such as acne, dermatitis, infectious disease, or trauma.
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Many forms of hyperpigmentation are caused by an excess production of melanin. [4] Hyperpigmentation can be diffuse or focal, affecting such areas as the face and the back of the hands. Melanin is produced by melanocytes at the lower layer of the epidermis. Melanin is a class of pigment responsible for producing color in the body in places such ...
The body undergoes many hormonal changes during menopause, which can trigger increased melanin production and increased hyperpigmentation in the skin, in addition to everything else, according to ...
Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis. [ 41 ] Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1, and TRP2, MART1 ...