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Image showing trophoblast differentiated into the two layers of cytotrophoblast and syncytiotrophoblast during implantation. It is the outer layer of the trophoblasts and actively invades the uterine wall, during implantation, rupturing maternal capillaries and thus establishing an interface between maternal blood and embryonic extracellular fluid, facilitating passive exchange of material ...
The formation of syncytiotrophoblast from cytotrophoblast is a terminal differentiation step of trophoblastic cells. [ 2 ] Syncytialization of cytotrophoblastic cells can be induced in vitro through multiple signalling molecules including epidermal growth factor , glucocorticoids , and human chorionic gonadotropin .
The cytotrophoblast is a layer of mono-nucleated cells that resides underneath the syncytiotrophoblast. [6] The syncytiotrophoblast is composed of fused cytotrophoblasts which then form a layer that covers the placental surface. [6] The syncytiotrophoblast is in direct contact with the maternal blood that reaches the placental surface.
As these trophoblasts penetrate, they fuse with their neighbours, terminally differentiating into a multinucleated tissue, a syncytium known as the syncytiotrophoblast. Between this layer and the blastocyst lies the cytotrophoblast. [28] [29]
After implantation, cytotrophoblast is the inner layer of the trophoblast, composed of stem cells which give rise to cells comprising the chorionic villi, placenta, and syncytiotrophoblast. After implantation, syncytiotrophoblast is the outermost layer of the trophoblast.
On approximately the seventh day of development, the trophoblast (cells that make up the outer part of the blastocyst) divides to form two separate layers: an inner cytotrophoblast layer, and an outer syncytiotrophoblast layer. Using enzymes, the syncytiotrophoblast penetrates the tissues of the mother, then it attaches to these tissues by ...
A cytotrophoblast cap penetrates through the fetus' syncytiotrophoblasts and reaches the maternal decidua, forming the anchoring villus. [1] [3] [4] The cytotrophoblast layer spreads and contacts the cytotrophoblast layers of neighboring anchoring villi, creating a continuous layer called the cytotrophoblastic shell.
The cytotrophoblast contains cuboidal epithelial cells and is the source of dividing cells, and the syncytiotrophoblast is a syncytial layer without cell boundaries. The syncytiotrophoblast implants the blastocyst in the decidual epithelium by projections of chorionic villi, forming the embryonic part of the placenta. The placenta develops once ...