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A catecholamine (/ ˌ k æ t ə ˈ k oʊ l ə m iː n /; abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine. [1] Catechol can be either a free molecule or a substituent of a larger molecule, where it represents a 1,2 ...
There are three structural isomers: 1,2-dihydroxybenzene (the ortho isomer) is commonly known as catechol, 1,3-dihydroxybenzene (the meta isomer) is commonly known as resorcinol, and 1,4-dihydroxybenzene (the para isomer) is commonly known as hydroquinone. [1]
Catechol (/ ˈ k æ t ɪ tʃ ɒ l / or / ˈ k æ t ɪ k ɒ l /), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula C 6 H 4 (OH) 2. It is the ortho isomer of the three isomeric benzenediols. This colorless compound occurs naturally in trace amounts.
Examples Are Dopamine and Adrenaline. For premium support please call: 800-290-4726 more ways to reach us
Norepinephrine degradation. Catechol-O-methyltransferase is shown in green boxes.[5] [6]Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. [7]
One of the most prominent pharmacological characteristics of epinine, its ability to raise blood pressure, was noted as early as 1910, by Barger and Dale, who reported that "methylamino-ethyl-catechol", as they called it, had about 1/7 x the pressor potency of epinephrine, but about 5 x the potency of dopamine ("amino-ethyl-catechol") in cat preparations. [14]
The related drug oxypertine shows high affinity for the serotonin 5-HT 2 and dopamine D 2 receptors (K i = 8.6 nM and 30 nM, respectively) and is also known to act as a catecholamine depleting agent. [ 9 ] [ 10 ] Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine , a serotonin receptor agonist , and ...
Brilliant blue FCF (Blue 1) is a synthetic organic compound used primarily as a blue colorant for processed foods, medications, dietary supplements, and cosmetics. [1] It is classified as a triarylmethane dye and is known under various names, such as FD&C Blue No. 1 or acid blue 9.