Ads
related to: renal failure in multiple myeloma- FAQs
Find FAQs For This Treatment
Option On The Official Patient Site
- Patient Resources
Find Patient Resources
On The Official Site.
- FAQs
Search results
Results From The WOW.Com Content Network
Kidney failure in multiple myeloma can be acute (reversible) or chronic (irreversible). Acute kidney failure typically resolves when the calcium and paraprotein levels are brought under control. Treatment of chronic kidney failure is dependent on the type of kidney failure and may involve dialysis.
Myeloma cast nephropathy, also referred to as light-chain cast nephropathy, is the formation of plugs (urinary casts) in the kidney tubules from free immunoglobulin light chains leading to kidney failure in the context of multiple myeloma. It is the most common cause of kidney injury in myeloma. [1]
At the time of diagnosis, 30% to 50% of light chain multiple myeloma patients have severe renal dysfunction or kidney failure due to light chain myeloma cast nephropathy or the nephrotoxic effects of free light chains on renal tubular cells. Patients are treated similarly to patients suffering the counterparts those with multiple myeloma except ...
LCDD is associated with multiple myeloma in 39-59% of cases, with monoclonal gammopathy of renal significance in 39% of cases and may also be associated with lymphoplasmacytic lymphoma. [2] The median 5-year overall survival of LCDD patients is 70%. [2]
Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of target organ manifestations such as kidney failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow. Bence Jones proteins are present in 2/3 of multiple myeloma cases. [3]
Multiple myeloma: kidney impairment is caused by the accumulation and precipitation of light chains, which form casts in the distal tubules, resulting in kidney obstruction. In addition, myeloma light chains are also directly toxic on proximal kidney tubules, further adding to kidney dysfunction.
Kidney cancer. Increased risks of non-Hodgkin lymphoma. Increased risks of liver cancer. Nerve damage. Heartbeat changes. Skin rashes. Autoimmune disease. Reproductive issues. Lower levels of ...
A kidney biopsy should be performed in all cases of MGRS to confirm the M-protein's causal relationship with regards to kidney disease. [1] The only exception is AL amyloidosis which can be diagnosed if AL deposits are detected in other tissues, such as peripheral fat. [5] Overt hematologic malignancies such as multiple myeloma should be ...
Ad
related to: renal failure in multiple myeloma