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Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Epidemiological and laboratory studies have identified Aristolochia to be a dangerous kidney toxin; Aristolochia has been shown to be associated with more than 100 cases of kidney failure. [30] Furthermore, it appears as if contamination of grain with European birthwort ( A. clematitis ) is a cause of Balkan nephropathy , a severe renal disease ...
The agency warned that consumption of aristolochic acid-containing products was associated with "permanent kidney damage, sometimes resulting in kidney failure that has required kidney dialysis or kidney transplantation. In addition, some patients have developed certain types of cancers, most often occurring in the urinary tract." [24]
What causes kidney disease? The most common causes of CKD are high blood pressure and diabetes, "which damage the small blood vessels and filtering units in the kidneys over time," says Nagata ...
The link between kidney failure and aristolochic acid, which the plant contains, was discovered after a clinic for obesity in Belgium used herbal products based on another plant of the same genus as a diuretic. After a few months, some of the patients experienced kidney failure.
Symptoms of ingestion generally include irritation and burning of the mouth, lips, and throat, nausea and vomiting, abdominal pain, diarrhea, muscle twitching, and sometimes swelling of the mouth or tongue, which can cause breathing to become fatally blocked. In severe cases chronic kidney disease or renal failure can occur. [71]
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