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Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. [ 5 ] [ 6 ] CTCF is involved in many cellular processes, including transcriptional regulation , insulator activity, V(D)J recombination [ 7 ] and regulation of chromatin architecture.
CTCF molecules can form homodimers on DNA, which can be co-bound by cohesin; this chromatin loop structure helps constrain the ability of enhancers within the loop to target genes outside the loop. Loops with CTCF and cohesin at the start and end of the loop that restrict enhancer-gene targeting are "insulated neighborhoods."
CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a ...
Carolinas Medical Center, formally known as Atrium Health Carolinas Medical Center, [1] is an 874-bed non-profit, tertiary, research and academic medical center located in Charlotte, North Carolina, servicing the southern North Carolina, northern South Carolina, and the Metrolina region. Carolinas Medical Center is one of the region's only ...
The gene therapy will compete with Australia-based CSL Behring’s Hemgenix, a similar treatment that won FDA approval for hemophilia B in 2022. That drug has a similar list price of $3.5 million ...
Atrium Health Mercy (formerly Mercy Hospital, later Carolinas Medical Center-Mercy) is a 185-bed adult health tertiary acute care facility located in the Elizabeth neighborhood of Charlotte, North Carolina. The hospital was established in 1906 by the Sisters of Mercy, and is the first Catholic hospital ever built in North Carolina.