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This accumulation results in therapeutic levels of terbinafine even after 80 days following one week treatment of 250 mg/day. Different dosing schedules have been proposed such as 500 mg/day for one week or 250 mg/day for two weeks each followed by a drug-free period of two or three weeks, totaling 3 months of treatment including the drug-free ...
The drug binds to tubulin, interfering with microtubule function, thus inhibiting mitosis. [10] It binds to keratin in keratin precursor cells and makes them resistant to fungal infections. The drug reaches its site of action only when hair or skin is replaced by the keratin-griseofulvin complex.
Equianalgesic charts are also used when calculating an equivalent dosage of the same drug, ... 10 mg ~25%: 2–4 3:1 30 min 3–6 hours Oxycodone [22]
The drug may cause adrenal insufficiency so the level of the adrenocortical hormones should be monitored while taking it. [13] [36] Oral ketoconazole at a dosage range of 400 to 2,000 mg/day has been found to result in a rate of gynecomastia of 21%. [37]
As of 2015 in the US, the 1% topical cream is generic OTC for about $15/oz. But the 250mg oral tablets require a prescription and retail for well over $1 per tablet -- yet are commonly covered by various discount programs that can bring the cost down to about $10 per month (30 tablets).
Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals: [22] elevated alanine aminotransferase levels are found in 4% of people taking itraconazole