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Regulation of gene expression gives control over the timing, location, and amount of a given gene product (protein or ncRNA) present in a cell and can have a profound effect on the cellular structure and function. Regulation of gene expression is the basis for cellular differentiation, development, morphogenesis and the versatility and ...
This is the simplistic DNA → RNA → protein pathway published by James Watson in the first edition of The Molecular Biology of the Gene (1965). Watson's version differs from Crick's because Watson describes a two-step (DNA → RNA and RNA → protein) process as the central dogma. [ 7 ]
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
Created by Jason Thomas, GEP4J is an open-source implementation of gene expression programming in Java. It implements different GEP algorithms, including evolving decision trees (with nominal, numeric, or mixed attributes) and automatically defined functions. GEP4J is hosted at Google Code. PyGEP – Gene Expression Programming for Python
Transcription is the process of copying a segment of DNA into RNA for the purpose of gene expression.Some segments of DNA are transcribed into RNA molecules that can encode proteins, called messenger RNA (mRNA).
The gene expression patterns that define cell identity are inherited through cell division. [1] This process is called epigenetic regulation . DNA methylation is reliably inherited through the action of maintenance methylases that modify the nascent DNA strand generated by replication. [ 1 ]
Cis-regulatory DNA sequences that are located in DNA regions distant from the promoters of genes can have very large effects on gene expression, with some genes undergoing up to 100-fold increased expression due to such a cis-regulatory sequence. [3] These cis-regulatory sequences include enhancers, silencers, insulators and tethering elements. [4]
Functional genomics focuses on the dynamic aspects such as gene transcription, translation, regulation of gene expression and protein–protein interactions, as opposed to the static aspects of the genomic information such as DNA sequence or structures. A key characteristic of functional genomics studies is their genome-wide approach to these ...