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7-Hydroxymitragynine (7-OH) is a terpenoid indole alkaloid from the plant Mitragyna speciosa, commonly known as kratom. [2] It was first described in 1994 [3] and is a human metabolite metabolized from mitragynine present in the Mitragyna speciosa. 7-OH binds to opioid receptors like mitragynine, but research suggests that 7-OH binds with greater efficacy.
Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. [4] It is an opioid that is typically consumed as a part of kratom for its pain-relieving and euphoric effects.
"indigenous ritual use indicates dose levels for T. corymbosa, and I. violacea which are far lower than that perceived as necessary to effect hallucinosis in members of modern Western cultures. In Mexico, the only place in the world where the ingestion of morning glory seeds has an established tradition of shamanic usage, a hallucinogenic dose ...
Mitragynine pseudoindoxyl is a μ-opioid receptor agonist and δ-opioid receptor antagonist.It is a G protein biased agonist at the μ-opioid receptor, which may be responsible for its favorable side effect profile compared to conventional opioids. [3]
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Salvia divinorum, a dissociative hallucinogenic sage. This is a list of plant species that, when consumed by humans, are known or suspected to produce psychoactive effects: changes in nervous system function that alter perception, mood, consciousness, cognition or behavior.
[137] [138] [139] While psychedelics themselves are also being clinically evaluated for these potential therapeutic benefits, non-hallucinogenic serotonin 5-HT 2A receptor agonists, which are often analogues of serotonergic psychedelics, have been developed and are being studied for potential use in medicine in an attempt to provide some such ...
[7] Galantamine was shown to increase lucid dreaming by 27% at 4 mg and 42% at 8 mg in a 2018 double-blind study lasting three nights. [8] Galanthus (genus) – An alkaloid in the plant is believed to increase the concentration of acetylcholine – a neurotransmitter that plays a very active role in dreaming [citation needed] Harmaline ...