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  2. High-grade prostatic intraepithelial neoplasia - Wikipedia

    en.wikipedia.org/wiki/High-grade_prostatic...

    High-grade prostatic intraepithelial neoplasia (HGPIN) is an abnormality of prostatic glands and believed to precede the development of prostate adenocarcinoma (the most common form of prostate cancer). [1] [2] It may be referred to simply as prostatic intraepithelial neoplasia (PIN).

  3. File:Histopathology of high-grade prostatic intraepithelial ...

    en.wikipedia.org/wiki/File:Histopathology_of...

    However, high magnification (right image) shows the key feature of prominent nucleoli (visible at 200x magnification to make the diagnosis of "high-grade"), as well as other typical features of HGPIN. Reference for features: - Margaret Sanders, M.B.B.Ch., Murali Varma, M.B.B.S.. High grade prostatic intraepithelial neoplasia (HGPIN).

  4. Histopathologic diagnosis of prostate cancer - Wikipedia

    en.wikipedia.org/wiki/Histopathologic_diagnosis...

    A pragmatic approach would be to recommend radical therapy only for extensive pure IDCP that is morphologically unequivocal for high-grade prostate cancer. [20] Active surveillance is not appropriate when low-grade invasive cancer is associated with IDCP, as such patients usually have unsampled high-grade prostatic adenocarcinoma. [20]

  5. NKX3-1 - Wikipedia

    en.wikipedia.org/wiki/NKX3-1

    LOH has been reported to be observed in 12-89% of high-grade prostatic intraepithelial neoplasia (PIN) and 35-86% of prostatic adenocarcinomas. The frequency of loss of heterozygosity on chromosome 8p is seen to increase with advanced prostate cancer grade and stage. [8]

  6. Intraepithelial neoplasia - Wikipedia

    en.wikipedia.org/wiki/Intraepithelial_neoplasia

    High grade anal intraepithelial neoplasia. Progression of pancreatic intraepithelial neoplasia, including mutations. [1] Cervical intraepithelial neoplasia (CIN), spanning a bit more than 2/3 of the thickness of the cervical epithelium. Intraepithelial neoplasia (IEN) is the development of a benign neoplasia or high-grade dysplasia in an ...

  7. Carcinoma in situ - Wikipedia

    en.wikipedia.org/wiki/Carcinoma_in_situ

    High-grade prostatic intraepithelial neoplasia is equivalent to CIS of the prostate. Bronchioloalveolar carcinoma (BAC) of the lung is the only form of CIS that can kill directly because, in rare cases (the "pneumonic form"), it expands greatly and fills the lungs, preventing breathing and causing other dire effects on the host.