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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices". [1]
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
This project is inspired by the 2009 Wikipedia AP Biology Project. There are many basic and important diagrams missing from biological articles and we're doing our part to fix this. Students will work alone, there are 49 students so we should have 49 new images with captions and labels. The time frame will be three weeks.
They are often found in signal transduction proteins. PTB-domain binding specificity is determined by residues to the amino-terminal side of the phosphotyrosine. Examples: the PTB domains of both SHC and IRS-1 bind to a NPXpY sequence. PTB-containing proteins such as SHC and IRS-1 are important for insulin responses of human cells.
This is an accepted version of this page This is the latest accepted revision, reviewed on 5 March 2025. American politician (born 1981) This article needs more complete citations for verification. Please help add missing citation information so that sources are clearly identifiable. (February 2025) (Learn how and when to remove this message) Tulsi Gabbard Gabbard in 2025 8th Director of ...
There is a project on GitHub since July 2014 to develop a new version of Power Tab from the scratch, called PowerTab 2.0. It's a cross-platform (Windows, Linux, OS X) open-source solution. This new version can read the old PowerTab 1.7 files as well as Guitar Pro files. A main change is that guitar and bass score are now in the same window.
In 2010, 8.8 million new cases of tuberculosis were diagnosed, and 1.20–1.45 million deaths occurred (most of these occurring in developing countries). [78] [171] Of these, about 0.35 million occur in those also infected with HIV. [172] In 2018, tuberculosis was the leading cause of death worldwide from a single infectious agent. [1]