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The first clinical trials in the United States involving mesenchymal stem cells occurred between 1996 and 2000 at the University Hospitals of Cleveland, while the hospital was also responsible for the first adult umbilical cord transplant in 1997, and the first adult stem-cell clinical trials in the country in 2003. [15] [16]
The FDA approved a phase I clinical trial with ViaCyte beta cells derived from human embryonic stem cell for the treatment of diabetes in August 2014. [15] The cells will be delivered in immunoprotective capsules and pre-clinical results in animal models showed remission of symptoms within a few months. [ 16 ]
Ohio State University is among the country's top public research institutions at #7. [2] Ohio is ranked in the top eight for states conducting clinical trials, including conducting the most clinical trials per capita. [3] In 2006, the state had a high-tech payroll of $9.8 billion, with 155,174 high-tech employees at 10,756 high tech locations.
Among several clinical trials reporting that adult stem cell therapy is safe and effective, actual evidence of benefit has been reported from only a few studies. [51] Some preliminary clinical trials achieved only modest improvements in heart function following the use of bone marrow stem cell therapy. [52] [53]
Cleveland Medical Center and Case School of Medicine together form the largest biomedical research center in Ohio. [ 8 ] In biomedical research, Case Medical Center ranks among top 15 centers in the United States with approximately $75 million in annual extramural research funding and a further $20 million in various clinical trials.
On November 22, 2010, the company announced that it had received approval from the U.S. Food and Drug Administration (FDA) to initiate the first human clinical trial using embryonic stem cells to treat retinal diseases. [11] A preliminary report of the trial published in 2012, [12] and a follow-up article was published in February 2015. [13]
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