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N,N-Dimethyltryptamine (DMT or N,N-DMT) is a substituted tryptamine that occurs in many plants and animals, including humans, and which is both a derivative and a structural analog of tryptamine. [1] [2] [3] DMT is used as a psychedelic drug and prepared by various cultures for ritual purposes as an entheogen. [9]
Topical atropine is used as a cycloplegic, to temporarily paralyze the accommodation reflex, and as a mydriatic, to dilate the pupils. [15] Atropine degrades slowly, typically wearing off in 7 to 14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ...
Pulmonary drug delivery is mainly utilized for topical applications in the lungs, such as the use of inhaled beta-agonists, corticosteroids and anticholinergic agents for the treatment of asthma and COPD, the use of inhaled mucolytics and antibiotics for the treatment of cystic fibrosis (CT) and respiratory viral infections, [1] and the use of inhaled prostacyclin analogs for the treatment of ...
Later analysis tentatively found 5-MeO-DMT in stems, leaves and roots; DMT, NMT and 5-MeO-DMT were tentatively observed in seeds, but follow-up tests were negative. [ 9 ] [ 53 ] Bark contains unidentified alkaloids [ 54 ] Bark in one sample subsequently found to contain an alkaloid which has an Rf value suggesting DMT.
Bufotenin, also known as 5-hydroxy-N,N-dimethyltryptamine (5-HO-DMT), is a substituted tryptamine and a derivative of dimethyltryptamine (DMT; N,N-dimethyltryptamine) and serotonin (5-hydroxytryptamine; 5-HT). It is also closely related to psilocin (4-HO-DMT) and 5-MeO-DMT. The predicted log P of bufotenin ranges from 0.89 to 2.04.
A 2018 study demonstrated that a single dose of 5-MeO-DMT induced neurogenesis in mice. [ 31 ] Similarly to other serotonergic psychedelics, 5-MeO-DMT is a non-selective serotonin receptor agonist , including of the serotonin 5-HT 1A , 5-HT 2A , 5-HT 2B , and 5-HT 2C receptors , among others.
DET, also known under its chemical name N,N-diethyltryptamine and as T-9, [2] is a psychedelic drug closely related to DMT and 4-HO-DET.However, despite its structural similarity to DMT, its activity is induced by an oral dose of around 50–100 mg, without the aid of MAO inhibitors, and the effects last for about 2–4 hours.
It is the α,N-dimethyl positional isomer of N,N-dimethyltryptamine (N,N-DMT). [1] α,N-DMT was first synthesized by Alexander Shulgin. [1] In his book TiHKAL (Tryptamines I Have Known and Loved), Shulgin lists the route as oral, the dosage as 50 to 100 mg, and the duration as 6 to 8 hours. [1]
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