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Aromatase inhibitors (AIs) are a class of drugs used in the treatment of breast cancer in postmenopausal women and in men, [1] [2] and gynecomastia in men. They may also be used off-label to reduce estrogen conversion when supplementing testosterone exogenously. They may also be used for chemoprevention in women at high risk for breast cancer.
Endocrine treatment may be beneficial for patients with hormone receptor positive breast tumors. [5] There are two ways for treating these kind of tumors: Lowering systemic levels of estrogen, achieved by the use of drugs from the aromatase inhibitor category. [6] [7] These drugs target one of the enzymes that takes part in the biosynthesis of ...
Estrogen deprivation therapy, also known as endocrine therapy, is a form of hormone therapy that is used in the treatment of breast cancer.Modalities include antiestrogens or estrogen blockers such as selective estrogen receptor modulators (SERMs) like tamoxifen, selective estrogen receptor degraders like fulvestrant, and aromatase inhibitors like anastrozole and ovariectomy.
About 80% of breast cancers feed off estrogen; therefore, suppression of this hormone is routinely recommended for treatment. The associated symptoms that come with losing the hormone are accepted ...
Tamoxifen is used for the treatment of both early and advanced estrogen receptor-positive (ER-positive or ER+) breast cancer in pre-and postmenopausal women. [24]
A study that used high- to very-high-dose oral estradiol to treat postmenopausal women with estrogen receptor-positive breast cancer found that mean steady-state estradiol levels in the 6 mg/day group were about 300 pg/mL and in the 30 mg/day group were about 2,400 pg/mL. [37]
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