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  2. HER2 - Wikipedia

    en.wikipedia.org/wiki/HER2

    As of November 2015, there are a number of ongoing and recently completed clinical trials of novel targeted agents for HER2+ metastatic breast cancer, e.g. margetuximab. [36] Additionally, NeuVax (Galena Biopharma) is a peptide-based immunotherapy that directs "killer" T cells to target and destroy cancer cells that express HER2. It has entered ...

  3. Triple-negative breast cancer - Wikipedia

    en.wikipedia.org/wiki/Triple-negative_breast_cancer

    Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name triple-negative). [1]

  4. Trastuzumab - Wikipedia

    en.wikipedia.org/wiki/Trastuzumab

    In early-stage HER2-positive breast cancer, trastuzumab-containing regimens improved overall survival (Hazard ratio (HR) = 0.66) and disease-free survival (HR = 0.60). [39] Increased risk of heart failure (RR = 5.11) and decline in left ventricular ejection fraction ( relative risk RR = 1.83) were seen in these trials as well. [ 39 ]

  5. Three-drug therapy ‘doubles breast cancer survival time ...

    www.aol.com/three-drug-therapy-doubles-breast...

    The trial included 325 patients from across 28 countries.

  6. What is stage I triple-positive breast cancer? - AOL

    www.aol.com/lifestyle/office-star-jenna-fischer...

    What is stage I triple-positive breast cancer? ... (HER2). About 10% of all breast cancers are triple positive. These three fuel sources allow these tumors to grow more rapidly than others but ...

  7. Eli Lilly's Investigational Cancer Drug Cuts Risk Of Death By ...

    www.aol.com/finance/eli-lillys-investigational...

    Imlunestrant is also being investigated in the adjuvant setting in people with ER+, HER2- early breast cancer with an increased risk of recurrence. This Phase 3 trial EMBER-4 is expected to enroll ...

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