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According to some newer sources, the ATP yield during aerobic respiration is not 36–38, but only about 30–32 ATP molecules / 1 molecule of glucose [12], because: ATP : NADH+H + and ATP : FADH 2 ratios during the oxidative phosphorylation appear to be not 3 and 2, but 2.5 and 1.5 respectively.
The observed yields are, therefore, closer to ~2.5 ATP per NADH and ~1.5 ATP per FADH 2, further reducing the total net production of ATP to approximately 30. [20] An assessment of the total ATP yield with newly revised proton-to-ATP ratios provides an estimate of 29.85 ATP per glucose molecule. [21]
Summary of aerobic respiration. Glycolysis is the metabolic pathway that converts glucose (C 6 H 12 O 6) into pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol). The free energy released in this process is used to form the high-energy molecules adenosine triphosphate (ATP) and reduced nicotinamide adenine ...
Though slower than glucose, its yield is much higher. One molecule of glucose produces through aerobic glycolysis a net of 30-32 ATP; [11] whereas a fatty acid can produce through beta oxidation a net of approximately 100 ATP depending on the type of fatty acid. For example, palmitic acid can produce a net of 106 ATP. [12]
ATP production occurs in the mitochondria of the cell. There are two methods of producing ATP: aerobic and anaerobic. In aerobic respiration, oxygen is required. Using oxygen increases ATP production from 4 ATP molecules to about 30 ATP molecules. In anaerobic respiration, oxygen is not required.
Glycolysis produces only 2 ATP molecules, but somewhere between 30 and 36 ATPs are produced by the oxidative phosphorylation of the 10 NADH and 2 succinate molecules made by converting one molecule of glucose to carbon dioxide and water, [6] while each cycle of beta oxidation of a fatty acid yields about 14 ATPs. These ATP yields are ...
For an odd-numbered saturated fat (C n), 0.5 * n - 1.5 oxidations are necessary, and the final process yields 8 acetyl CoA and 1 propionyl CoA. It is then converted to a succinyl CoA by a carboxylation reaction and generates additional 5 ATP (1 ATP is consumed in carboxylation process generating a net of 4 ATP).
The dephosphorylation of ATP and rephosphorylation of ADP and AMP occur repeatedly in the course of aerobic metabolism. [ 19 ] ATP can be produced by a number of distinct cellular processes; the three main pathways in eukaryotes are (1) glycolysis , (2) the citric acid cycle / oxidative phosphorylation , and (3) beta-oxidation .