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The purpose of a dialyzer is to separate the analyte from interfering substances such as protein, whose large molecules do not go through the dialysis membrane but go to a separate waste stream. The reagents, sample and reagent volumes, flow rates, and other aspects of the instrument analysis depend on which analyte is being measured.
Kolff's first prototype dialyzer was developed in 1943, built from orange juice cans, used auto parts, and sausage casings. [3] Over a two-year span, Kolff had attempted to treat 15 people with his machine, but all had died. In 1945, Kolff successfully treated his first patient, a 67-year-old woman, from kidney failure using his hemodialysis ...
Automated coagulation machines or Coagulometers measure the ability of blood to clot by performing any of several types of tests including Partial thromboplastin times, Prothrombin times (and the calculated INRs commonly used for therapeutic evaluation), Lupus anticoagulant screens, D dimer assays, and factor assays.
A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such systems focus either on removing the accumulating toxins (liver dialysis), or providing additional replacement of the metabolic functions of the liver through the inclusion of hepatocytes to the device (bioartificial liver device).
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The prototypes contained human renal cells which stayed healthy for the duration of the 7 day trial implantation in healthy juvenile Yucatan pigs (n=5). Further testing with a greater number of kidney cells in the devices on pigs with kidney failure will be needed to show the bioreactor can perform physiologically similar functions to a natural ...
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