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Antioxidants & Redox Signaling is a peer-reviewed scientific journal covering reduction–oxidation (redox) signaling and antioxidant research. It covers topics such as reactive oxygen species/reactive nitrogen species (ROS/RNS) as messengers gaseous signal transducers, hypoxia and tissue oxygenation, microRNA, prokaryotic systems, and lessons from plant biology.
Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Free radicals are part of redox molecules and can become harmful to the human body if they do not reattach to the redox molecule or an antioxidant. The term redox state is often used to describe the balance of GSH/GSSG, NAD + /NADH and NADP + /NADPH in a biological system such as a cell or organ.
Reductive stress (RS) is defined as an abnormal accumulation of reducing equivalents despite being in the presence of intact oxidation and reduction systems. [1] A redox reaction involves the transfer of electrons from reducing agents (reductants) to oxidizing agents (oxidants) and redox couples are accountable for the majority of the cellular electron flow. [2]
As part of their adaptation from marine life, terrestrial plants began producing non-marine antioxidants such as ascorbic acid (), polyphenols, and tocopherols.The evolution of angiosperm plants between 50 and 200 million years ago resulted in the development of many antioxidant pigments – particularly during the Jurassic period – as chemical defences against reactive oxygen species that ...
Studies on cells meanwhile suggest that ergothioneine can help prevent DNA damage from UV exposure, according to a 2022 review of studies published in the journal Antioxidants & Redox Signaling ...
Deleting antioxidant enzymes, in general, yields shorter lifespan, although overexpression studies have not (with some exceptions) consistently extended lifespan. [52] Study of a rat model of premature aging found increased oxidative stress , reduced antioxidant enzyme activity and substantially greater DNA damage in the brain neocortex and ...
22166 Ensembl ENSG00000136810 ENSMUSG00000028367 UniProt P10599 P10639 RefSeq (mRNA) NM_003329 NM_001244938 NM_011660 RefSeq (protein) NP_001231867 NP_003320 NP_035790 Location (UCSC) Chr 9: 110.24 – 110.26 Mb Chr 4: 57.94 – 57.96 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Thioredoxin (TRX or TXN) is a class of small redox proteins known to be present in all organisms. It ...