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Side effects from intra-articular administration can include joint pain, swelling, lameness, and, rarely, infection of the joint. Intramuscular injection can cause dose-dependent inflammation and bleeding, since PSGAG is an analogue of the anticoagulant heparin. [4] In dogs, this may manifest as bleeding from the nose or as bloody stools. [7]
[35] [41] Amikacin is also injected into the joints with the anti-arthritic medication Adequan in order to prevent infection. [42] Side effects in animals include nephrotoxicity, ototoxicity, and allergic reactions at IM injection sites. Cats tend to be more sensitive to the vestibular damage caused by ototoxicity.
The term injection encompasses intravenous (IV), intramuscular (IM), subcutaneous (SC) and intradermal (ID) administration. [35] Parenteral administration generally acts more rapidly than topical or enteral administration, with onset of action often occurring in 15–30 seconds for IV, 10–20 minutes for IM and 15–30 minutes for SC. [36]
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subcutaneous "SC" can be mistaken for "SL," meaning sublingual. See also SQ: sem. semen seed s.i.d. semel in die: once a day used exclusively in veterinary medicine sig. signa, signetur: write (write on the label) s̄ sine: without (usually written with a bar on top of the s) sing. singulorum: of each SL, s.l. sub lingua
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Pentosan polysulfate, like Adequan, has been shown to improve signs of osteoarthritis. In non-equine models, Pentosan has been shown to increase proteoglycan synthesis, [40] stimulate hyaluronic acid production in osteoarthritic joints (a benefit not shared by PSGAGs), [41] reduce inflammatory cytokines, and improve damaged articular cartilage ...