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Side effects can include fatigue, anemia, muscle aches, fever, and/or swelling in the feet or legs. Flu-like symptoms are common after the first infusion, although not subsequent infusions, and are thought to occur because of its potential to activate human gamma delta T cell (γδ T cells).
Particular medications can result in MRONJ, a serious but uncommon side effect in certain individuals. Such medications are frequently used to treat diseases that cause bone resorption such as osteoporosis, or to treat cancer. The main groups of drugs involved are anti-resorptive drugs, and anti-angiogenic drugs.
Reclast (zoledronic acid or zoledronate) is approved by the Food and Drug Administration (FDA) to treat and prevent osteoporosis in males, females after menopause, and people taking ...
Long-term treatment with bisphosphonates produces anti-fracture and bone mineral density effects that persist for 3–5 years after an initial 3–5 years of treatment. [2] The bisphosphonate alendronate reduces the risk of hip, vertebral, and wrist fractures by 35-39%; zoledronate reduces the risk of hip fractures by 38% and of vertebral ...
Injection site reactions (ISRs) are reactions that occur at the site of injection of a drug. They may be mild or severe and may or may not require medical intervention. Some reactions may appear immediately after injection, and some may be delayed. [1] Such reactions can occur with subcutaneous, intramuscular, or intravenous administration.
Bariatric surgery can cause substantial and sustained weight loss but is generally recommended in cases of severe ... the adverse effects of muscle loss associated with GLP-1-induced weight loss ...
Deprescribing is an option for patients who experience unpleasant side effects, said Sue Clenton, MD, a consultant clinical oncologist at Weston Park Cancer Centre in Sheffield, U.K.
Zoledronate is the most potent bisphosphonate drug today only available as intravenous injection. It is the only bisphosphonate drug that has two nitrogen groups in the side chain hence its potency and route of administration differs from other drugs in the same class. [16]